Bipolar Disorder and Parkinson disease: a 123I-FP-CIT SPECT study

Introduction Bipolar Disorder (BD) has been suggested to be a risk factor for development of Parkinson Disease. Psychiatric drugs used as standard treatment BD includes many that are known induce drug-induced parkinsonism (DIP). Objectives Clinical differentiation between PD and DIP is clinical scientific crucial result. It might aided by functional neuroimaging the dopaminergic nigrostriatal pathway. Methods Twenty consecutive patients with were clinically assessed underwent 123 I-ioflupane dopamine transporter SPECT. Imaging data pathological pathway further compared population de-novo patients. Results Four had abnormal scans; they higher putaminal binding ratio putamen-to-caudate ratios than patients, despite similar motor symptom burden. Conclusions in our initial results, up 20% have an underlying deficit, which excepted general population. This evidences supports represents subsequent neurodegenerative parkinsonism. Disclosure Interest None Declared